Your GPS for Health
Reverse Chronic Disease by Tackling Root Causes
Coming to Amazon Soon
Summary
Over the past century, chronic diseases — including obesity, diabetes, cardiovascular disease, autoimmune disorders, autism, neurodegenerative diseases, mental illness, and cancer — have risen dramatically. Today, few families remain untouched by at least one of these conditions. For example, obesity has reached epidemic proportions, and autism prevalence has increased nearly fivefold in just twenty-two years. If current trends continue, nearly half the population in developed countries will develop cancer at some point during their lifetime by 2040.
We have been led to believe that these illnesses are inevitable — written in our DNA or simply an unavoidable consequence of aging — and that the only option is lifelong dependence on prescription drugs or, worse, helplessly watching disease progress.
This is far from the truth. Our genes have changed little over the past eighty years. While aging naturally brings some wear and tear, it does not inherently cause chronic diseases such as obesity, diabetes, or cancer. Most importantly, as this book demonstrates, most chronic diseases can be prevented or reversed once their root causes are identified and addressed.
Grounded in fifteen years of rigorous scientific research yet written in clear, accessible language, this book examines the factors behind the dramatic rise in chronic disease over the past eight decades and offers practical, evidence-based strategies to prevent and reverse these conditions by eliminating their underlying triggers.
About the Author
Jian Gao, PhD, is a healthcare analyst and researcher with over thirty years of experience. Throughout his career, Dr. Gao has focused on pursuing truth and evidence rather than following trends or prevailing narratives. Instead of publishing to expand his résumé, he has dedicated his work to identifying and rectifying misconceptions that are widely accepted as unquestionable truths in mathematical statistics and medicine.
Dr. Gao’s research has uncovered critical flaws in two of the most widely used statistical metrics — p-values and R-squared — showing that they were fundamentally misconceived and misapplied, leading to exaggerated interpretations of treatment effects and the strength of evidence. His findings on R-squared have far-reaching implications for Quantitative Genetics and effectively put an end to the widespread “Bad Luck Theory” of cancer derived from two high-profile articles published in Science.
He has proven that the Cox proportional hazards model — developed in one of the 100 most-cited scientific papers ever published — has likewise been misconceived and misused in medical research, resulting in widespread exaggeration of treatment effects. In addition, he has scientifically demonstrated that randomized controlled trials, despite being universally regarded as the gold standard of medical research, systematically produce biased results when studying chronic diseases.
Dr. Gao has challenged several long-standing tenets of public health and medicine. For example, he has scientifically demonstrated that salt intake is not the root cause of the hypertension epidemic and that worldwide guidelines promoting very low salt intake are detrimental to public health. He is the first to present systematic evidence showing that sun exposure is not the root cause of the skin cancer epidemic over the past eighty years. He is also the first to challenge the universally accepted dogma that aging is a leading cause of cancer and to demonstrate, with mathematical certainty, that man-made toxic chemicals are the principal driver of the soaring incidence of cancer over the past eight decades.
About the Editor
Frederick Malphurs is a visionary healthcare executive whose thirty-seven-year career embodies public service, integrity, and sustained results. Inspired by President Kennedy’s call to serve, he devoted his career to serving the public, relocating his family thirteen times across the country to advance patient care.
As CEO of multiple major hospitals, Mr. Malphurs was known for strategic clarity, disciplined execution, and a rare ability to build high-performing teams. While leading a network of six hospitals and dozens of outpatient clinics in Upstate New York, he led a sustained system-wide turnaround — transforming the system from the bottom tier into top national rankings in both quality and cost effectiveness.
Over the course of his career, he also oversaw national programs involving billions of dollars, earning a reputation for principled stewardship and an unwavering commitment to the public interest. He consistently rejected the “revolving door” with private contractors, maintaining a clear focus on mission over personal or political gain.
His leadership is characterized by selfless public service, a steadfast long‑term vision, unparalleled magnanimity in assembling the most talented teams in service of the mission, and an unwavering commitment to motivating staff through transparent recognition and accountability. Throughout his career, his guiding principle has been a singular focus on what best serves patient care and public interest.